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Symptoms caused by over-stimulation of muscarinic receptors can be recalled using the DUMBBELS mnemonic (Diarrhea, Urination, Miosis, Bronchorrhea/Bronchoconstriction, Bradycardia, Emesis, Lacrimation, Salivation)
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Synergistic combinations can achieve the desired therapeutic effect at lower doses, thus reducing the risk of side effects and toxicity compared to high doses of a single natural compound, which generally exhibit lower toxicity than synthetic drugs
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