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The formation of a likely Wnt-Fz-LRP6 complex together with the recruitment of the scaffolding protein Dishevelled (Dvl) results in LRP6 phosphorylation and activation and the recruitment of the Axin complex to the receptors
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CROs, in turn, are expected to do more than deliver studies, they are expected to help orchestrate risk, integrate data across regions, and translate complexity into control
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