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Another important finding is that the AChE activity which has been linked to the pathology of MS (Di Bari et al., 2016), was significantly decreased in mice treated with VA, IBD, and VA + IBD (Figure 6B) confirming the enhancement of remyelination

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However, a Phase 2 clinical study evaluating ANS-6637 in treatment-seeking adults was terminated early due to concerns of liver toxicity (307), and efficacy results for a clinical trial using a hepatic ALDH2 mRNA inhibitor (DCR-AUD) are not yet publicly available (NCT05845398)