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Several recombinant monomeric or multimeric SARS-CoV-2 proteins were produced tagged with a Nanoluciferase reporter (Promega, Madison, Wisconsin, USA): the whole spike glycoprotein S1 + S2 (a derivative of the previously described trimeric S1 + S2 spike protein 42 ) or its parts: the S2 protein and the glycoprotein RBD, the nucleocapsid protein (NP), the spike S2 proteins of the HCoV-OC43 and HCoV-HKU1 beta coronaviruses and the hemagglutinin HA1 protein of the 2009 H1N1 pandemic flu virus (Supplementary Fig