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Garvey explains how combining amylin and GLP-1 receptor agonism may enhance weight loss and glycemic control while maintaining tolerability, and explores the potential role of amylin therapies in the future management of obesity and type 2 diabetes

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Researchers have proposed several non-exclusive frameworks, including blood-brain-barrier transport of an endogenous peptide, interaction with the stress axis, circadian and pineal signalling via the alpha-1-adrenergic receptor (PMID 3029331), and neuroprotective activity