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For patients who are not candidates for surgical resection, liver transplantation, or local ablative therapies, systemic treatments become the cornerstone of clinical management

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Like other mitophagy receptors, FUNDC1 possesses a canonical LIR motif in its N-terminal cytosolic region, which facilitates interaction with Atg8 family proteins and induces the selective removal of mitochondria (Wang and Wang, 2023)