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For example, as the chemical moiety interacting with the E3 enzyme CRBN 106,108 , the phthalimide ring was used as the E3 recruiter, whereas a competitive BET bromodomain inhibitor, JQ1 was used to bind the bromodomain protein BRD4 109 (Figure 5B), a transcriptional co-activator that regulates the expression of genes that promote cancer cell proliferation and survival 110