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In drug-induced pyridoxine deficiency, such as in patients taking isoniazid, a higher replacement dose is often used, for example, 100 mg IV or IM daily for 3 weeks, to rapidly correct the deficiency, followed by a maintenance dose of around 30 mg daily
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For moderate cases, oral supplements containing cyanocobalamin or methylcobalamin are commonly prescribed to replenish B12 stores
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