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31% of 183 patients respectively in the SUNRISE trial) and with secukinumab every 4 weeks versus placebo in the SUNRISE trial (46% of 180 patients vs
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Modern molecular pathophysiology studies have confirmed that oxidative stress plays an important part in various pathological changes in CNS, such as hypoxic/toxic injury, metabolic disturbance, inflammation and oncogenesis.1, 28, 60, 110, 127 Specifically, ROS and RNS could be overproduced under various CNS pathogenesis such as abnormal cell metabolism, mitochondrial damage and calcium overload, which disturbed the balance between physical oxidative reaction and antioxidative system and thus generated lipid, protein peroxidation or DNA damage on the neurons which lead to the damage of neurons.48 Previously, ROS were considered more as a detrimental substance which might cause cell damage and lead to various pathological process in CNS