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An experiment conducted on Apo E knockout mice fed a high-fat diet to induce atherosclerosis, along with in vitro studies on macrophage-derived foam cells, has confirmed that HO-1 plays a dual role in ferroptosis: low expression enhances cell viability and reduces lipid peroxidation, whereas high expression can induce ferroptosis in macrophage-derived foam cells (13)

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As a component of the E3 subunit of the pyruvate dehydrogenase complex (PDC), its primary function is to catalyze the dehydrogenation of dihydrolipoamide and convert it into oxidized lipoamide (46)