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In patients receiving planned on-off VEGFi treatment cycles, antihypertensive medications may be held during off-therapy periods due to expected BP normalization
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The following keywords and MeSH terms were employed—individually or in combination—to identify relevant studies: “natural bioactive products,” “flavonoids,” “phenolics,” “saponins,” “polysaccharides,” “terpenoids,” “osteogenesis,” “bone regeneration,” “osteoporosis,” “osteoblasts,” “osteoclasts,” “angiogenesis,” “bone marrow-derived mesenchymal stem cells (BMSCs),” “Wnt/β-catenin,” “BMP/Smad,” “phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt),” “Mitogen-activated protein kinase (MAPK),” “Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB),” “Janus kinase (JAK)/signal transducer and activator of transcription (STAT),” “Nuclear factor erythroid 2–related factor 2 (Nrf2)/glutathione peroxidase 4 (GPX4),” “ferroptosis,” “oxidative stress,” “immune modulation,” “Classically activated macrophage (M1)/alternatively activated macrophage (M2) polarization,” “regulatory T cells (Tregs),” “gut microbiota,” “gut–bone axis,” “Receptor activator of nuclear factor κB ligand (RANKL)/osteoprotegerin (OPG),” “drug delivery,” and “biomaterial scaffolds.” Boolean operators (AND, OR) were used to optimize search sensitivity and specificity
Glutathione is the bodys primary antioxidant