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A randomized, double-blind, placebo-controlled study conducted in 40 patients with type 2 diabetes with microalbuminuria found that high-dose thiamin supplementation (300 mg/day) decreased excretion of urinary albumin over a three-month period (87)

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Mannoheptulose is a well-known inhibitor of hexokinase and glucokinase—enzymes responsible for phosphorylating glucose in the first step of glycolysis [66]