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Notably, supplementation may reduce the required dose and duration of exogenous gonadotropins during controlled ovarian stimulation and is linked to higher pregnancy rates in ART cycles (148), primarily when used in combination with D-chiro-inositol at a physiological 40:1 ratio (149)
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This implies a dependency on rerouting metabolic fluxes for maintaining antioxidant defenses and survival after lethal oxidative damage, ultimately pointing to metabolic plasticity as a driver of radiosensitivity 53,107,108
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