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That human orthologs of Sll1147 could rescue the stress tolerance of a Synechocystis PCC 6803 mutant lacking Sll1147 showed that the function of this MAPEG-type GST has been conserved during evolution from cyanobacteria to humans

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some are challenging to be used in clinical trials due to significant side effects while others continue to be in the hypothetical stage and have not been proven effective in treating COPD