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Redox regulation of CRMP2 during development of the zebrafish brain requires activity of the vertebrate-specific Grx2 (Bräutigam et al., In vitro analyses demonstrated a Cys504-Cys504 thiol-disulfide switch that determines distinct conformations of the homotetrameric protein (Gellert et al., 2 O 2 generation through the monooxygenase MICAL (Morinaka et al., Conclusion The intention of this article was to underscore the priority of enzyme catalysis vs