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Thus, the tight balance between the NRF2/HIF-1α axis regulates BBB preservation and health

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Although this enzyme is receiving considerable attention for its role in various physiological functions (Sakamoto et al., At least one type of plant methionine sulphoxide reductase activity may be coupled to GSH oxidation via glutathione-linked GRX (Tarrago et al., 2 O 2 -triggered S -glutathionylation of diverse available protein cysteine residues, followed by regeneration of the free cysteines by glutathione-dependent GRX (Zaffagnini et al., 2 O 2 to two water molecules with oxidation of 2 GSH to GSSG, i.e., a GSH peroxidase reaction