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10.1111/j.1398-9995.2007.01389.x 10 CarmelR

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How Cortisol Imbalance Affects the Whole Body Chronic HPA dysfunction doesn’t only affect energy levels—it can ripple out into all major systems of the body: Digestive health : Cortisol suppresses enzyme output and impairs gut lining integrity Immune system : It reduces secretory IgA and weakens frontline defences Thyroid function : High cortisol impairs thyroid hormone conversion Metabolic health : Long-term stress contributes to insulin resistance and central weight gain Mood and cognition : Cortisol affects neurotransmitters and memory centres like the hippocampus The Inflammation Link: Cortisol Resistance When cortisol is elevated over time, the body can become resistant to its signals — similar to insulin resistance