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In humans, inorganic sulfate is activated through ATP and magnesium-dependent PAPS synthase (PAPSS1 or PAPSS2a/b) and then incorporated into biomolecules such as glycoproteins, glycosaminoglycans (GAGS), cholesterols, or even proteins in sulfonation/sulfurylation reactions by several sulfotransferase enzymes (SULTs/TPSTs)

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