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It’s been noted that folic acid fortification in food helps to lower the prevalence of neural tube defects by about 50% to 70%

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The frequency of MTHFR homozygous genotype 677CC was 89% in the vitamin B-12 group and 85% in the placebo group ( P = 0.18), and the frequency of homozygous 677TT was 0.6% in both groups ( P = 1.00)