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Wild-type C57BL/6 mice, After a week of intraperitoneal injection with the CD38 inhibitor 1 (compound 78c) at a dose of 15 mg/kg every 2 days, a single intraperitoneal (i.p.) injection of LPS was administered 24 h after the last dose

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The quaternary salt is generally hydrolytically stable at neutral pH but can undergo ring-opening or demethylation under strongly acidic or alkaline conditions