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Here are some common side effects of tretinoin: Skin irritation Peeling and flaking Increased sensitivity to sun Dryness Skin redness Tingling or burning sensation May cause hyperpigmentation in skin of color due to irritation 20 Increased breakouts in the beginning of the treatment (commonly referred to as tretinoin purging) It is recommended that women stop using tretinoin one month before planning a pregnancy, during pregnancy, and until they are nursing