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FIGURE 7 AST ameliorates DNA damage and cellular senescence in HK-2 cells exposed to IS DNA damage and senescent phenotype of renal tubular epithelial cells are distinctive features of CKD progression ( Regarding DNA damage, the results of the alkaline comet assay showed that compared with the Control group, there was a significant increase in the DNA damage level ( P 0.05) (Figure 8A)

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Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice