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Indeed, several additional metabolic targets of p53 also contribute to its ferroptotic response and the defects in p53-mediated ferroptosis caused by an African-specific polymorphism in the TP53 gene impair its tumor suppressor function [[420], [421], [422], [423]]
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Furthermore, the glutamate levels in the brain are far higher than those in plasma of mice, rats, guinea pigs and rabbits (26)
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