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The expression of CYP2J, a member of P450 subfamily with a role in the bioactivation of AA in extrahepatic tissues, inhibits NF-κB and MAPK signaling pathways and activates of PPARγ, thus reducing IR and diabetic phenotype [173]

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Although previous studies had examined the effects of intra-articular GH injections on cartilage repair, few had compared the use of GH analogs or peptides like AOD9604 in combination with HA