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This ROS-MAPK-PAD4 axis represents the convergent signaling cascade through which diverse pathological stimuli, including 2,4,6-trinitrobenzenesulfonic acid (TNBS) (124), phorbol 12-myristate 13-acetate (PMA), monosodium urate (MSU) crystals (125, 126), LPS (127), diabetes-associated hyperglycemia (128), and hypochlorous acid (HOCl) (129), ultimately trigger NETosis
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Shandong Provincial Key Medical and Health Discipline of Endocrinology, Shandong Provincial Key Medical and Health Laboratory of Endocrinology and Endocrinology Diseases (Affiliated Hospital of Shandong Second Medical University)