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Withdrawal rates due to adverse effects serve as a practical measure of real-world tolerability, as they reflect whether side effects are bothersome enough to outweigh potential benefits

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Additionally, CD38 is upregulated in the heart following ischemia–reperfusion injury, the CNS in a variety of neurodegenerative and neuroinflammatory diseases, in tumorigenesis, and in muscle, liver and articular cartilage during aging 11,31,53,54