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Indeed, melatonin is highly permeable to cell membranes and easily crosses the blood–brain barrier 51 , ensuring a good therapeutic profile for brain diseases, and is also able to accumulate into mitochondria, probably via GLUT/SLC2A and PEPT1/2 carriers 52,53
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Evidence that formulations of the selective MAO-B inhibitor, selegiline, which bypass first-pass metabolism, also inhibit MAO-A in the human brain
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