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The outcome: tesamorelin demonstrated “favorable effects on cognition in both adults with [mild cognitive impairment] and healthy older adults.” Although adverse events were reported in 68% of tesamorelin subjects, the events themselves were mild — primarily localized skin reactions and increased joint pain.22 Cardiovascular health By shrinking visceral fat, tesamorelin effectively reduces a major cardiovascular risk factor.23 There’s even a recent paper examining the direct relationship between tesamorelin and cardiovascular disease