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[0591] In some embodiments, the polynucleotides disclosed herein can be formulated as a nanoparticle using a combination of polymers, lipids, and/or other biodegradable agents, such as, but not limited to, calcium phosphate

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Enzymatic conjugation, catalyzed by the enzyme glutathione-S-transferase, occurs in Phase II liver detoxification and in gastrointestinal mucosal secretions