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Dysregulated ferroptosis contributes significantly to diverse pathologies, including ischemia-reperfusion injury (cardiac, cerebral, renal) (Shan et al., 2024), neurodegenerative disorders, diabetic complications, atherosclerosis, and cancer progression or therapy resistance (Wang et al., 2024)
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The mature melanin is then transported through dendritic structures and later distributed to adjacent keratinocytes, ultimately synthesizing keratin