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however, it improved pain scores in patients with DPN in a phase 2 study

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With severe syndromes, such as vascular and multiorgan failure following major vessel occlusion or similar noxious procedures [66,71,72,73,74,75,76,77,78,79,80,81,82], the particular activation of the collateral pathways (i.e., azygos vein direct blood delivery) might be essential to counteract severe central and peripheral lesions, intracranial (superior sagittal sinus), portal and caval hypertension and aortal hypotension