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TNF‐alpha suppresses SHOX2 expression via NF‐kappaB signaling pathway and promotes intervertebral disc degeneration and related pain in a rat model

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doi: 10.3389/fped.2025.1645600 Received 25 June 2025 Accepted 14 August 2025 Published 02 September 2025 Volume 13 - 2025 Edited by Elsayed Abdelkreem, Sohag University, Egypt Reviewed by Mohamed Elshinawy, Alexandria University, Egypt Aditi Kumar, All India Institute of Medical Sciences, India Francesca di Sario, Polytechnic University of Marche, Italy Updates Copyright © 2025 Xing, Guo, Li, Zhou, Lin and Wang