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The increase in FFA can promote the secretion of pro-inflammatory cytokines such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) ( (2) Phospholipid Metabolism Imbalance: As depressive symptoms worsen, serum levels of lysophospholipids (lysophosphatidylcholine [LPC], lysophosphatidylethanolamine [LPE]) significantly increase, while levels of alkyl phosphatidylethanolamine (O-alkyl phosphatidylethanolamine [PE-O]), which possesses antioxidant function, decrease ( (3) Sphingolipid Metabolism Abnormalities: Plasma ceramide (Cer) levels are also significantly increased in depressed patients compared to healthy controls and correlate with the severity of the Hamilton Depression Rating Scale (HAMD-D) ( Table 3 compares the lipid dysregulation profiles between depression patients and preclinical models