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Reactive Oxygen Species Reactive species (RS) are a broad term and include ROS, nitrogen [reactive nitrogen species (RNS)], sulfur [reactive sulfur species (RSS)], and other species, several of which are free radicals, and each has the potential to cause oxidative stress as a result of their accumulation within the cell to a level that exceeds the capacity to remove them (Mittler, 2017)

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Genetics of amyotrophic lateral sclerosis: an update