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Well-known signaling pathways, such as the mitogen-activated protein kinase (MAPK), nuclear factor kappa-B (NF-κB), Wnt, transforming growth factor-β (TGF-β), Notch, Hippo, Janus kinase (JAK)/signal transducer and activator of transcription (STAT), Hedgehog (Hh), and phosphoinositide 3-kinase (PI3K)/AKT pathways, as well as transcription factors, including heat shock transcription factor 1 (HSF1), hypoxia-inducible factor (HIF), Snail, P53, and Twist, constitute complex regulatory networks to modulate the formation, activation, heterogeneity, metabolic characteristics and malignant phenotype of cancers ( The current therapeutic strategies for treating cancer, include radiation therapy, surgery, chemotherapy, molecular targeted therapy, immunotherapy and antibody-drug conjugate (ADC)
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