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Maximum dose 7.2 mg once weekly Consider treatment response and tolerability when selecting the maintenance dosage Pediatric patients' weight reduction maintenance dose (patients aged 12 years and older): Either 2.4 mg (recommended) or 1.7 mg once weekly

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The thyrotropin (TSH) receptor transmembrane domain mutation (Pro556-Leu) in the hypothyroid hyt/hyt mouse results in plasma membrane targeting but defective TSH binding