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Currently, no mTOR peptide inhibitors have been tested for PKD, but in 2017, the first polypeptide named small regulatory polypeptide of amino acid response (SPAR) (MGAKAPRGPKVAQWAMETAVIGV-VVVLFVVTVAITCVLCCFSCDSRAQDPQGGPGRSFTVATFRQEASLFTGPVRHAQPVPS AQDFWTFM) was found to suppress mTORC1 activity by analyzing and transcribing cytosolic RNA sequences previously thought to be non-coding [111, 112]
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Table 3 presents genes that are upregulated, and Table 4 presents genes that are down regulated
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