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Vitamin B12 deficiency symptoms Deficiency progresses slowly, sometimes over years, and its symptoms get mistaken for stress or "just getting older." Watch out for: Tiredness and weakness that don't improve with rest Tingling or numbness in hands and feet Pale or slightly yellowish skin A swollen, smooth or burning tongue Memory problems and trouble concentrating Mood changes, irritability or low mood Dizziness or shortness of breath with exertion Balance problems when walking If you have several of these symptoms, a simple blood test confirms or rules out the deficiency