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Preclinical studies demonstrate that dual inhibition of c-MET and TGF-β pathways synergistically reduces tumor growth, metastasis, and immune evasion, highlighting the potential of this approach (43)
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Moreover, immune-inflammatory responses and autoimmune reactions can lead to decreased mitochondrial membrane potential activity, increased mitochondrial membrane permeability, disruption of ATP production, reduction in creatine phosphate synthesis, and consequent adverse effects on oxidative phosphorylation []