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Observed by the researchers in both in vivo and vitro settings, simvastatin significantly reduced ICAM-1 and LFA-1 expression on monocytes and endothelial cells, at a genomic (mRNA) and proteomic level [284]

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Medication use, recent dental procedures, and possible sources of localized infection (skin, respiratory, gastrointestinal, or genitourinary) are documented, as these can guide anatomic and etiologic localization of lymphadenopathy