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Moreover, cancer cell metabolism is highly dynamic in response to various environmental stresses, such as hypoxia 30,31 or cytotoxic therapies such as chemotherapy or radiation therapy 32,33

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Piatti PM, Monti LD, Valsecchi G, Magni F, Setola E, Marchesi F, et al Long-term oral L-arginine administration improves peripheral and hepatic insulin sensitivity in type 2 diabetic patients Diabetes Care