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47 Gallego-Colon et al 66 found that exenatide could down-regulate the expression of protein hydrolases MMP-1, MMP-2 and MMP-9 and increase the protein concentration of TIMP-1 and TIMP-2 by inhibiting protein kinase B-Thr308 phosphorylation, PRAIS40 and S6 protein signaling pathways in smooth muscle