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PE-22-28 exhibits unique pharmacological properties through TREK-1 channel blockade, offering rapid-onset therapeutic effects with improved tolerability compared to traditional antidepressants, making it distinctive among neurotherapeutic peptides

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Interestingly, mitochondria can scavenge exogenous H 2 O 2 at a rate of 9–12 nmol/min/mg mitochondrial protein in a respiration- and substrate-dependent manner, which is 100 times higher than the H 2 O 2 production rate