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Among the list of Major Modifications for 2025 is that guanfacine has been clarified not to be a prohibited substance

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More recently, the randomized phase II EVI-2 trial in low-risk myeloid malignancies (MDS + MDS/MPN) and Clonal Cytopenia of Undetermined Significance (CCUS) found that daily oral vitamin C supplementation was associated with a promising signal for longer overall survival compared to placebo (221)