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Furthermore, resveratrol prevents the degeneration of dopaminergic neurons in substantia nigra by improving the number of positive tyrosine hydroxylase cells, inhibits aggregation of the α-synuclein protein and glucose-regulated protein 78 (a stress marker of endoplasmic reticulum in the brain), protects the Na + /K + ATPase pump and the expression of CYP2d22 mRNA (it is considered to protect against Parkinson’s disease), increases acetylcholinesterase enzyme, ATP and the expression of the vesicular monoamine transporter mRNA 2 [3,44,45,46]
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