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In one study, investigations of skeletal muscle cells in CFS patients indicated elevated myogenin expression under basal conditions, impaired activation of AMP-activated protein kinase (AMPK), and diminished stimulation of glucose uptake []

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The most immediate and evident role is mechanical: due to the specialized organization of the cytoskeleton, RBC adopts a biconcave shape that maximizes the surface-to-volume ratio, enhancing gas exchange, while simultaneously maintaining exceptional deformability [59,60]