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Effect of Glutathione Infusion on Leg Arterial Circulation, Cutaneous Microcirculation, and Pain-Free Walking Distance in Patients With Peripheral Obstructive Arterial Disease: A Randomized, Double-Blind, Placebo-Controlled Trial - Mayo Clinic Proceedings

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89 When mitochondrial fusion is suppressed by the down-regulation of OPA1, resulting in elevated ROS levels while an decrease in antioxidant enzyme levels, finally contributing to oxidative stress and cellular damage