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Despiste the wide variability in maturation timelines and functional benchmarks across different iHLO differentiation protocols 10,15,16,29,30,31 , our findings contribute a valuable reference for guiding hepatic organoid development, especially for optimizing their use in preclinical research and tailored applications such as drug metabolism and toxicology

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But the popular idea of a “detox”—flushing out years of accumulated chemicals—is not supported by evidence