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Indeed, the inhibition of γGT or cysteine S -conjugate β-lyase (both highly expressed in proximal tubule cells of the kidney) blocks the nephrotoxicity of cisplatin in mice (Townsend et al., 2003)

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Arginine salt formulations show particularly high oral bioavailability with only 15.1 percent degradation after five hours at pH 3.0 versus 99 percent destruction of standard acetate forms