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Clifford the Big Red Dog (2021) - Tony Hale as Tieran - IMDb

Although the mechanisms of the downregulation of opioid receptors in DRG neurons after peripheral nerve injury are still unintelligible, additional shreds of evidence revealed that this downregulation occurs at multiple levels, with changes in related key molecules affecting the number and function of opioid receptors (Table 2) and involving different molecular mechanisms of NP

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